Name: α-Ketoglutaric Acid
Brand: Xi'an Natural-Field Bio-Technique Co., Ltd.
Availability: InStock

Advantages of α-Ketoglutaric Acid

Multiple certification qualifications.

Complete import and export procedures.

20 years of experience in nutritional and health ingredients.

Detail of α-Ketoglutaric Acid

I. Chemical Structure and Properties

1. Structural Characteristics - It is an α - keto acid, and its chemical name is 2 - oxoglutaric acid. Its chemical formula is C5H6O5.

2. Physical Properties - It is usually a white crystalline or crystalline powder. It is soluble in water, slightly soluble in ethanol, and insoluble in ether. It has a certain acidity because the carboxyl group in its molecule can ionize hydrogen ions.

II. Role in Organisms

1. Role in the Tricarboxylic Acid Cycle (TCA Cycle) - In the aerobic metabolism process of cell respiration, α - ketoglutaric acid is a key intermediate product of the tricarboxylic acid cycle. It is generated by the oxidative decarboxylation of isocitric acid under the action of isocitrate dehydrogenase. Then, α - ketoglutaric acid continues to participate in subsequent reactions and undergoes oxidative decarboxylation reaction catalyzed by the α - ketoglutarate dehydrogenase complex to generate succinyl-CoA. This process produces reduced coenzyme I (NADH) and carbon dioxide. NADH can enter the electron transport chain to produce ATP (adenosine triphosphate). - For example, in the mitochondria of the human body, the TCA cycle is constantly operating, and α - ketoglutaric acid is like a "transfer station", promoting the process of energy metabolism and providing energy for cells.

2. Amino Acid Metabolism - α - ketoglutaric acid is also very important in the synthesis and catabolism of amino acids. It can be interconverted with some amino acids through transamination. For example, a reversible transamination reaction can be catalyzed by glutamate dehydrogenase between glutamate and α - ketoglutaric acid. In this reaction, glutamate loses an amino group and becomes α - ketoglutaric acid, and at the same time, α - ketoglutaric acid gains an amino group to generate glutamate, which plays a key role in maintaining the balance of amino acids in the body.

3. Association with Other Metabolic Pathways - It is also related to some other metabolic pathways. For example, in the process of glutamine synthesis, α - ketoglutaric acid can participate as a raw material. In some tissues, glutamine synthetase uses glutamate and ammonium ions and consumes α - ketoglutaric acid to synthesize glutamine, which is of great significance for the transport and metabolism of ammonia.

α-Ketoglutaric Acid

Certificate of α-Ketoglutaric Acid

ltem	Specification	Result	Method
Assay	>99.00%	99.5%	HPLC
B1Afatoxin B1	≤5.0ppb	Conforms	LCMS
Appearance	Fine Powder	Conforms	Organoleptic
Color	White Powder	Conforms	Organoleptic
Odor&Taste	Characteristic	Conforms	Organoleptic
Physical&chemical Characteristics
Particle Size	95%Through 80 mesh	Conforms	Sieving
Loss on Drying	≤5.0%	3.8%	USP
Ash	≤5.0%	3.2%	USP

Loose Density	Actual Value	0.51g/'ml	USP
Tight Density	Actual Value	3.2%	USP
Residual Solvents	Actual Value	0.51g/ml	USP
Pesticide Residue	Actual Value	0.69g'ml	USP
Heavy Metals	≤10ppm	Conforms	USP
Lead(Pb)	≤1.0ppm	Conforms	USP
Arsenic(As)	≤1.0ppm	Conforms	USP
Mercury(Hg)	≤0.1ppm	Conforms	USP
Cadmium(Cd)	≤1.0ppm	Conforms	USP
MicrobiologicalTests
Total plate Count	<5000cfu/g	Conforms	USP
Ycast& Mold	≤100cfu/g	Conforms	USP
E.Coli.	Negative	Negative	USP
Salmonella	Negative	Negative	USP
Staphylococcus	Negative	Negative	USP
Conclusion	Confomm to In-house standard

Deliver & Shipping

We accept International Express--Fedex/DHL/UPS, air shipping and sea shipping, We can ship to all over the world, even to some remote areas, such as remote areas of Russia, countries near the north and south poles.

Alpha Ketoglutarate