Ashwagandha Extract (Withanolides)

What is Ashwagandha Extract?

Ashwagandha, also known as Indian ginseng, is a herb widely used in traditional medicine. Ashwagandha extract is the essence extracted from the root of ashwagandha.

Ashwagandha extract contains a variety of active ingredients, among which the most important are withanolides. These withanolides have various biological activities such as antioxidant, anti-inflammatory, and anti-stress effects. In addition, ashwagandha extract also contains a variety of nutrients such as vitamins, minerals, and amino acids.

What Are the Characteristics of Good Ashwagandha Extract?

• High purity: Good Ashwagandha extract should have high purity, free of impurities and pollutants. Our Ashwagandha extract comes in three specifications: 10%, 5%, and 2.5%, and is produced in a purification workshop without impurities and pollutants.

• Standardized content: The active ingredient, coumarin, should have a standardized content to ensure the stability and reliability of its efficacy. Our drunk eggplant extract has been tested by the authoritative testing agency SGS to meet USP-NF standards.

• High quality sources: from reliable planting bases and manufacturers, ensuring the quality and safety of raw materials. We import Ashwagandha plants from India and produce them in GMP factories in China.

• Good solubility: easy to dissolve and use in various dosage forms.

Functions of Ashwagandha Extract (Withanolides)

Anti-anxiety and anti-depression

Ashwagandha extract significantly improved anxiety and depression symptoms in an 8-week clinical trial. Compared to the placebo group, participants taking Ashwagandha extract showed a clear advantage in alleviating anxiety symptoms, and this effect may be related to a reduction in cortisol levels.

(Chandrasekhar et al., 2012)

Antioxidant

Ashwagandha extract has significant antioxidant properties. itreduces oxidative stress by enhancing the activityof antioxidantenzymes in the body, such as SOD, CAT, and GSH, promoting cellrepair and exhibiting anti-aging effects. Studies show that the withanolides in Ashwagandha can reduce cell damage caused by hydrogen peroxide, demonstrating powerful antioxidant effects.

(Vijayakumaret al., 2008)

Immune regulation

Ashwagandha extract has immune-boosting effects, primarily by stimulating the function of macrophages and enhancing the activity of T cells to regulate the immune system. lts immune-modulating mechanism may be related to the direct effects of its active compounds on immune cells.

(Bhat et al., 2010)

Endocrine regulation and stress resistance

Ashwagandha extract alleviates chronic stress responses by regulating the hypothalamic-pituitary-adrenal (HPA) axis. By effectively reducing cortisol levels under prolonged stress, it helps restore hormonal balance in the body and improves stress-related physical fatigue, sleep quality, and mental well-being.

(Auddy et al., 2008)

Neuroprotection Promotion

Ashwagandha extract is considered to have neuroprotective effectsparticularly in preventing neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. its mechanisms of action involve antioxidant, anti-inflammatory properties, as well as promoting the expression of nerve growth factor (NGF).

(Mishra et aL, 2000)

Anti-inflammatory

Ashwagandha extract also has anti-inflammatory properties. alleviates inflammatory responses by inhibiting the release of inflammatory factors in the body, such as TNF-α, IL-1B, and IL-6.Additionally, it reduces cell damage caused by inflammation through its antioxidant effects.

(Singh et al, 2011)

Summary

The specific biological mechanisms of Ashwagandha extract are still under continuous research. Scientists and research institutions worldwide are actively exploring them. Due to its potential effects in neuroendocrine regulation, immunomodulation, antioxidant and anti-inflammatory activities, this extract is being increasingly applied in the nutraceutical field and has attracted significant attention.

NF Ashwa Efficacy Verification

NF Ashwas Ashwagandha Extract "Verified by Zebrafish" efficacy certification has been obtained

The experimental phenotype and column chart for the effect of sample are shown in Figure 1 and Figure 2 below.

Figure 1. The behavioral typical diagram after NF Ashwa  Ashwagandha Extract treatment.

The black line is slow motion, the green line is medium movement, and the red line is fast movement.

Figure 2. The total movement distance after NF Ashwa Ashwagandha Extract treatmentCompared with model group, *p<0.05, **p<0.01

It was observed that the the total movement distance in zebrafish in the NF Ashwa Ashwagandha Extract group was significantly reduced compared with the model control groupindicating that NF Ashwa Ashwagandha Extract has relief anxiety effect.

Figure 1.The number of residual fluorescent particles after NF Ashwa' Ashwagandha Extract treatment The red fluorescent particles are fluorescent microspheres

Figure 2. The number of residual fluorescent particles after NF Ashwa Ashwagandha Extract treatmentCompared with model group, ***p<0.001

It was observed that the number of residual fluorescent particles in zebrafish in the NF Ashwa Ashwagandha Extract group was significantly reduced compared with the model control groupindicating that NF Ashwa  Ashwagandha Extract has enhanced immune effect.

Application prospects of Ashwagandha Extract

• Health care field: Due to its antioxidant, anti-inflammatory, and anti-stress effects, ashwagandha extract has broad application prospects in the field of health care. It can be used to relieve stress, improve sleep, and enhance immunity.

• Sports nutrition field: For athletes and fitness enthusiasts, ashwagandha extract can help improve endurance, reduce fatigue, and promote recovery.

• Beauty and skin care field: Its antioxidant effect can help reduce the damage of free radicals to the skin, delay skin aging, and at the same time improve the elasticity and luster of the skin. In conclusion, as a natural treasure of health, ashwagandha extract has broad application prospects. With the increasing attention of people to health and natural therapies, it is believed that ashwagandha extract will play an increasingly important role in the fields of health care, sports nutrition, and beauty and skin care in the future.

Solutions Offered

Sleep lmprovement

NF Ashwa°+ L-theanine, GABA.

lmmune System Boosting

NF Ashwa + Curcumin, Reishi, Vitamin C

.

Anxiety Relief and Stress Resistance

NF Ashwa + L-theanine, 5-HTP

Men's Health

NF Ashwa + Maca Extract, Ginseng Extract, Tribulus Terrestris Extract, TongkatAli Extract, Pygeum Africanum Extract, and Homy Goat Weed Extract.

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