From Botanical Active Innovation to Precision Delivery – Natural Field Unveils the NFTriSolve® Sleep Health Solution at WPE&WHPE 2026

Xi'an, August 24 – The 2026 Brain Health & Sleep-Emotion Application Innovation Forum, hosted by WorldBosen (Beijing) Expo Service Group and Food Research & Development FTA, kicked off at the Xi'an International Convention and Exhibition Center during WPE&WHPE 2026. Natural Field Co., Ltd. was invited to attend, and Professor Li Chong from Southern Medical University, the company's Functional Raw Materials R&D Lead, delivered a keynote presentation titled "From Botanical Active Innovation to Precision Delivery – The Technological Upgrade and Scientific Exploration of the NFTriSolve® Sleep Health Solution." The speech systematically unveiled the complete technical pathway from Ashwagandha active innovation to brain-targeted delivery, drawing keen attention from the audience.

Sleep Health: Moving from "Ingredient Competition" to "Science-Driven" Era

The presentation opened with a telling set of data—"poor sleep quality" has now overtaken "difficulty falling asleep" as the primary consumer concern: frequent dreaming (49.36%) and nocturnal awakenings (47.44%) are even more prevalent than difficulty initiating sleep (44.87%). Consumers are no longer satisfied with "high dosage and trending ingredients." Instead, they demand proof of efficacy: absorption rate, mechanism of action, and solid empirical data have become the new benchmarks for decision-making.

The concept of sleep health is also evolving: from "falling asleep fast and relieving insomnia" to "deep sleep, sleep continuity, and next-day performance." The future lies in a systematic approach that integrates sleep, emotional well-being, stress management, and brain health—building a closed-loop "sleep-emotion-cognition" ecosystem.

Ashwagandha: A Scientific Revival of a Classic Adaptogen

At the heart of the NFTriSolve® Sleep Health Solution is Ashwagandha (Withania somnifera), a classic adaptogen from Ayurvedic medicine. Its various withanolide constituents each play a distinct role:

• Withanoside IV – primary sleep-promoting factor with anxiolytic effects

• Withanolide A – neuroprotection and cognitive enhancement

• Withaferin A – anti-inflammatory and immunomodulatory effects

Its mechanism involves activating the HPA axis and regulating cortisol levels, thereby reducing stress responses, alleviating anxiety, and improving sleep quality.

Through years of dedicated research, Natural Field has established a comprehensive Ashwagandha innovation platform: Active Ingredient Research (withanolide isolation, identification, and activity evaluation system), Process Innovation (patented water-soluble debittering technology addressing poor solubility and bitter taste), and Application Development (multi-formulation compatibility and synergistic combinations). The company has also filed an invention patent for "Withanic acid compounds and their salts, preparation methods and applications."

Co-loaded Liposomes: Precision Brain-Targeted Delivery

The technological highlight of the presentation was the co-loaded liposome delivery system introduced by NFTriSolve®. It directly addresses four major industry pain points—poor water solubility, inadequate stability, low bioavailability, and difficulty in multi-component synergy—achieving a 2–8 fold increase in bioavailability.

What makes it even more original is the membrane innovation: replacing conventional cholesterol with Ashwagandha-derived ingredients to construct a novel "Ashwagandha liposome" system, distinct from traditional cholesterol-based liposomes. A comprehensive chain of experimental evidence has been established:

• The Ashwagandha liposome stably encapsulates melatonin, forming a uniform and stable nano-delivery system;

• In cerebrovascular endothelial cells and neuronal cells, internalization efficiency of Ashwagandha liposomes significantly exceeded that of cholesterol liposomes;

• Both in vivo and ex vivo experiments confirmed clear brain-targeted delivery function; at 1h, 2h, 4h, and 8h post-administration, withanolide concentrations in the brain were significantly higher in the Ashwagandha liposome group than in the free withanolide group;

• In a CORT-induced neuronal stress model, the Ashwagandha liposome@melatonin group showed significantly superior improvements in stress indicators (p<0.001).

Dual-Dimension Zebrafish Validation: 39% Behavioral Improvement, Three Gene Targets Simultaneously Optimized

In an AAALAC-accredited laboratory, using a zebrafish model sharing 87% genetic homology with humans, the study tested 9 proprietary formulations against 4 control groups (including commercial melatonin-containing and melatonin-free products, as well as a pure melatonin group):

• Behavioral level: Wakeful activity reduced by 39%, total wake time shortened by 34%—outperforming commercially available products;

• Molecular mechanism level: Simultaneous upregulation of GABA receptor gene (gabra1, +52%) and melatonin receptor gene (mtnr1aa, significantly upregulated), and downregulation of the wake-promoting neuropeptide (hcrt, significantly downregulated).

The mechanism of action is clearly defined, and the data are fully verifiable, providing brand customers with quantifiable, evidence-based efficacy support.

From "Sleep Aids" to "Sleep Health Management" – An Industry Transformation

At the forum, Natural Field also outlined the broader NFTriSolve® series roadmap. Following the earlier launches of MitoAge Complex (anti-aging) and JointFlex Complex (bone & joint health), sleep health represents the fourth piece of the puzzle, with future plans to cover emotional well-being and metabolic health.