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Poor sleep quality and frequent nighttime awakenings represent a health niche that functional food brands most want to enter yet find hardest to validate. Leveraging its co-loading liposome delivery platform and zebrafish models, Xi’an Tianfeng Bio-tech completed formula screening for the sleep direction and launched the NF TriSolve® Sleep Health Solution, with its optimal carrier being Target Formula , which ranked first in experiments.
In the AAALAC-accredited zebrafish insomnia model by Hunter Biotech, Target Formula 6 at only 141 µg/mL concentration achieved:
Awakening movement distance reduced to 1048±67.3 mm, sleep improvement efficacy 39%
Total awakening duration reduced to 28.2±1.60 s, improvement 34%
At gene level, simultaneously up-regulated gabra1 (52%), mtnr1aa (41%), and down-regulated hcrt (32%)
Compared with the imported AGZ Deep Sleep Purple Powder (2167 µg/mL, behavioral improvement only 17%) tested in the same session, Target Formula 6 delivered superior results at less than 1/10 the dosage, proving it is not a simple stacking of raw materials but a product of NF TriSolve® synergistic design.
The experiment used 5-day-old AB strain zebrafish, with PTZ-induced insomnia, and evaluated two dimensions:
Behavioral — recording awakening movement distance and total duration to calculate improvement rate;
Genetic — qPCR measured GABA receptor, melatonin receptor, and orexin gene expression.
Target Formula 6 was the only group that ranked first in both “less movement + stable genes”, with clear mechanism and verifiable data.
Developing sleep products, the three biggest fears are: too costly to run in-house efficacy with fish, claims lacking evidence leading to penalties, and high dosage causing cost blowout.
NF TriSolve® Sleep Health Solution directly provides:
Ready-made “behavior + gene” dual reports, labeled Verified by Zebrafish for science storytelling;
Low dosage with high efficacy, saving raw material costs;
Natural Field Co., Ltd., a 20-year ingredient manufacturer with CNAS/FSSC22000 certifications, enabling one-click OEM/ODM landing.
MitoAge Complex (Anti-aging): NMN + CoQ10 co-loading liposomes etc., anti-aging efficacy 97%, bioavailability increased 157%–160%;
JointFlex Complex (Joint care): 1/5 dosage achieving 2x cartilage repair;
Sleep Health (this article’s protagonist): fills the fourth puzzle piece of the platform, with emotional and metabolic directions to follow.
This is the last one.
