What is NFTriSolve®?

NFTriSolve® is a plant-derived co-loaded liposome health solution launched by Xi’an Natural Field Biotechnology Co., Ltd. (Natural Field Co., Ltd.). Built around plant-derived active ingredients, it delivers functional actives precisely to in-vivo targets through a proprietary co-loaded liposome delivery technology, and is supported by a four-tier progressive validation system (Mechanism → Pharmacokinetics → Efficacy → Human), enabling end-to-end scientific verification from mechanism to effect.

The core logic of “TriSolve” is a complete technical pathway: plant active innovation → precise delivery technology → scientific evidence system. These three pillars are tightly interlinked, forming a quantifiable, presentable and verifiable health solution platform.

Core Technology: Plant-Derived Co-Loaded Liposomes

What Are Co-Loaded Liposomes?

Conventional functional ingredients generally face four major challenges: poor water solubility, insufficient stability, low bioavailability, and difficulty in achieving multi-component synergy. NFTriSolve® leverages co-loaded liposome technology as a systematic answer to these pain points — it builds a dual-delivery system of “four-ring structured plant actives (withanolides, ginsenosides, etc.) + functional actives (melatonin, NMN, glucosamine, etc.)”, boosting bioavailability by 2–8 times.

Four Core Advantages

Four-Tier Progressive Validation System

NFTriSolve® builds a complete validation chain from mechanism to human application, ensuring that the efficacy of every solution is quantifiable and its advantages verifiable:

Tier 1: Mechanistic Evidence

Caco-2 cell model validates absorption efficiency and transmembrane transport mechanisms.

Tier 2: Pharmacokinetic Evidence

Animal pharmacokinetic studies quantify the fold-increase in bioavailability.

Tier 3: Efficacy Evidence

Zebrafish multi-model system rapidly screens and validates formulation efficacy.

Tier 4: Human Evidence

Real-population human trial confirms perceived improvement and safety.

Zebrafish Model Validation

Key validations of NFTriSolve® rely on the AAALAC internationally accredited zebrafish laboratory. Zebrafish share up to 87% gene homology with humans, and offer the advantages of short experimental cycles, large sample sizes and intuitive results.

Three Application Scenarios

NFTriSolve® currently covers three health scenarios — sleep, joint & bone, and oral anti-aging — forming a complete solution matrix.

1. Sleep Health Solution (SleepRestore Complex)

Core approach: Centered on low-dose melatonin liposomes, it promotes quality sleep by regulating the circadian rhythm, balancing neurotransmitters and relieving anxiety.

Key ingredients: Ashwagandha active ingredients + melatonin co-loaded liposomes + supporting actives including GABA, magnesium glycinate, L-theanine, 5-HTP, vitamin B6 and apigenin.

Scientific validation:

Behavioral level: In the zebrafish model, NFTriSolve® significantly reduced wakeful activity by 39% and shortened total wake time by 34%, outperforming commercial competitors in overall effect.

Molecular mechanism level: It simultaneously up-regulated the GABA receptor gene (gabra1, +52%) and the melatonin receptor gene (mtnr1aa, significantly up-regulated), while down-regulating the wake-promoting neuropeptide (hcrt, significantly down-regulated).

Dose advantage: A 2 mg dose delivered effects comparable to the 5 mg positive control — a 129% improvement over competitors at the gene level and an 18.2% improvement at the behavioral level.

Human validation: After 28 days of intake, stratum corneum water content increased from 31.02 ± 9.70 to 50.62 ± 10.72 (+63.19%, p<0.001), as verified by Corneometer® testing.

2. Joint & Bone Care Solution (JointFlex Complex)

Core approach: Multi-pathway synergistic repair achieves efficient cartilage repair and exercise recovery at an extremely low dose.

Key ingredients: Rare ginsenosides, glucosamine, chondroitin, vitamin D3, AKG calcium.

Scientific validation:

Versus positive control (chondroitin sulfate A sodium salt): Only 228 mg is required (less than one quarter of the 1000 mg positive control), delivering 2× cartilage repair and 2.3× exercise recovery.

Versus commercial glucosamine compound products: Only 228 mg is required (19.6% of the 1165 mg commercial product), delivering 1.3× cartilage repair and 1.6× exercise recovery.

Zebrafish model validation: Cartilage repair efficacy improved to 92% (positive control: only 39%), and activity recovery efficacy improved to 113% (positive control: only 46%).

3. Oral Anti-Aging Solution (MitoAge Complex)

Core approach: NMN co-loaded liposomes promote cellular energy metabolism, while coenzyme Q10 enhances mitochondrial function, achieving multi-dimensional anti-aging.

Key ingredients: NMN co-loaded liposomes, coenzyme Q10 co-loaded liposomes, ergothioneine, N-acetylneuraminic acid.

Scientific validation:

Absorption efficiency: Co-loaded liposomes achieved 3.71× and 2.77× absorption for coenzyme Q10 and NMN, respectively (ordinary liposomes: only 1.96× and 1.45×).

Bioavailability: Compared with ordinary raw materials, co-loaded liposomes increase bioavailability by 5.7–7.8 times.

Five-dimensional efficacy validation: In the zebrafish model — anti-aging 97%, collagen increase 68%, elastin increase 95%, skin brightening 106%, hydration 76% — the synergistic effect is significantly superior to single ingredients.

International comparison: Anti-aging efficacy 97% vs. 17% for an international benchmark product; collagen increase 68% vs. 25% for the international benchmark.

NFTriSolve® vs. Traditional Solutions

The Unique Value of NFTriSolve®

NFTriSolve® is not a single product, but a health solution platform driven by delivery technology, designed systematically, and validated by a complete evidence chain. It turns plant-derived active ingredients from mere “concepts” into functional raw materials that are truly “absorbed, utilized and verified” — providing brand customers with scientific support in which efficacy is predictable and advantages are quantifiable.