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According to the official statistics from the World Health Organization (WHO), in 2019 alone, the number of global deaths caused by cardiovascular diseases (CVDs) reached 17.9 million, accounting for 32% of total global deaths. More than 75% of these CVD-related deaths occurred in low- and middle-income countries. Additionally, the Report on Cardiovascular Health and Diseases in China 2022 shows that in 2020, the number of CVD patients in China reached 330 million, and 2 out of every 5 deaths were caused by CVDs.
Since 1961, the American Heart Association (AHA) has recommended improving dietary patterns to protect cardiovascular health. In recent years, with the enhancement of consumers' health awareness, they have sought to intervene in and maintain cardiovascular health through nutritional supplements.
In the cardiovascular nutraceutical market, Coenzyme Q10 (CoQ10) is undoubtedly the star ingredient. Data from Magic Mirror Insights shows that from January 2024 to March 2025, the total sales volume of CVD-related nutraceuticals on three major online platforms (Tmall, JDmall, Douyin) reached 7.74 billion yuan, with a year-on-year increase of 18.4%; the sales quantity reached 30.381 million units, a year-on-year growth of 34.1%. CoQ10 (41.4%) and fish oil (26.5%) accounted for nearly 70% of the market. From the perspective of market trends, the consumer base for CoQ10 is trending younger, especially favored by subhealthy young people.
Coenzyme Q10 (CoQ10), also known as ubiquinone and decaprenylquinone, is a compound integrating medical and nutraceutical functions. It has effects such as antioxidation, activating cellular respiration, and enhancing human immunity, and is widely used in the fields of cardiovascular health, anti-aging, and energy supplementation. In June 2021, the Catalog of Five Health Food Raw Materials Including Coenzyme Q10 was officially implemented, initiating the nationwide filing work for five health food raw materials including CoQ10. Currently, CoQ10 can be declared for two health functions: "antioxidation" and "enhancing immunity". In addition, the Chinese Expert Consensus on the Diagnosis and Treatment of Fulminant Myocarditis in Adults points out that all patients with fulminant myocarditis should receive routine symptomatic and supportive treatment, and substances such as creatine phosphate and CoQ10 can be administered to improve myocardial energy metabolism.
Despite its significant health benefits, CoQ10 has long been restricted by low bioavailability and slow absorption. After over a decade of continuous R&D investment, Natural Field Biotechnology has successfully developed CoQ10 liposomes and CoQ10 co-loaded liposomes, which can effectively improve the in vivo absorption and bioavailability of CoQ10, providing a new solution for such products.
NFLipo® CoQ10 Co-loaded Liposomes innovatively use rare ginsenosides as membrane materials, significantly improving the stability and biocompatibility of liposomes. This design not only gives full play to the antioxidant properties of CoQ10 but also combines the unique immunomodulatory function of rare ginsenosides, achieving a dual synergistic effect. Ordinary liposomes are tiny vesicles composed of lecithin and cholesterol, capable of encapsulating fat-soluble or water-soluble drugs, and serve as an ideal drug delivery system. However, they have a single formulation, a single function, and limited drug-loading capacity, making them more suitable for drugs or health foods with low dosage requirements.
Rare ginsenosides can not only improve the delivery efficiency of CoQ10 in the body but also further enhance its bioavailability. This synergistic effect enables CoQ10 co-loaded liposomes to have broad application prospects in the fields of nutritional health, medicine, and cosmetics.
Animal experiment data show that compared with traditional CoQ10, the bioavailability of CoQ10 encapsulated in co-loaded liposomes is increased by approximately three times. In a transport experiment simulating intestinal absorption using the Caco-2 cell model, the transport rate of CoQ10 co-loaded liposomes was increased by 7.86 times. This indicates that co-loaded liposomes significantly improve the in vivo absorption of CoQ10 and enhance its in vivo bioavailability.
Transmission Electron Microscopy (TEM) Image of NFLipo® CoQ10
Source: Targeted Drug Delivery Laboratory, School of Pharmacy, Southwest University
1) Cardioprotective Effects
To verify the efficacy of CoQ10 co-loaded liposomes, researchers from the Targeted Drug Delivery Laboratory, School of Pharmacy, Southwest University used C57BL/6 mice and induced myocardial injury via isoprenaline (ISO) injection to simulate a human cardiac injury model. The mice were randomly divided into multiple groups, including the control group, ISO model group, ordinary liposome group, ginsenoside liposome group, CoQ10-ginsenoside co-loaded liposome group, and CoQ10 soft capsule group. The experiment used multiple techniques such as echocardiography, serum marker detection, and oxidative stress marker testing to comprehensively evaluate the cardioprotective effects of different treatment groups.
Source: Targeted Drug Delivery Laboratory, School of Pharmacy, Southwest University
Note: The experiment was conducted over 21 days, with ISO injection on Day 0 and treatment intervention from Day 0 to Day 21.
The experimental results showed that the cardiac function of mice in the ISO model group significantly decreased, manifested by a significant reduction in left ventricular ejection fraction (EF) and fractional shortening (FS). After intervention with CoQ10-ginsenoside co-loaded liposomes, these indicators were significantly improved, with effects superior to those of commercially available CoQ10 soft capsules. This indicates that CoQ10 co-loaded liposomes can not only effectively reverse the impairment of cardiac function but also provide more durable and significant protective effects.
Further serum analysis found that the levels of ISO-induced myocardial injury markers, such as cardiac troponin I (cTnI) and B-type natriuretic peptide (BNP), increased significantly. However, CoQ10 co-loaded liposomes could significantly inhibit the increase in these markers, demonstrating their significant role in improving myocardial injury. In addition, the detection results of oxidative stress markers (such as malondialdehyde (MDA) and lactate dehydrogenase (LDH)) also showed that CoQ10 co-loaded liposomes could effectively alleviate oxidative stress responses and reduce cell membrane damage, further verifying their cardioprotective effect.
2) Anti-inflammatory Effects
The experiment also examined the regulatory effect of CoQ10 on cardiac inflammation. The study found that the levels of pro-inflammatory cytokines (such as IL-6, IL-1β, and TNF-α) in the serum of mice in the ISO group increased significantly, while CoQ10 co-loaded liposomes could significantly reduce the levels of these cytokines, indicating its significant advantage in anti-inflammation. In particular, compared with commercially available CoQ10 soft capsules, CoQ10 co-loaded liposomes showed a stronger effect in inhibiting the inflammatory response.
CoQ10 co-loaded liposomes not only show strong efficacy in cardioprotection but also have multiple effects of anti-inflammation and antioxidation, far exceeding those of traditional CoQ10 soft capsules. As a professional supplier of CoQ10 co-loaded liposome raw materials, Natural-Field Biotechnology can provide customers with more efficient and stable nutritional supplement solutions. Natural-Field Biotechnology believes that with the continuous advancement of scientific research, CoQ10 co-loaded liposomes will become an important choice in the field of cardiac health care in the future.
With the continuous innovation in the health field, Natural-Field Biotechnology looks forward to cooperating with customers from all walks of life to jointly promote the application of CoQ10 in nutritional health care. Whether you are a research institution, a pharmaceutical enterprise, or an end consumer, choosing Natural-Field Biotechnology's high-quality CoQ10 powder bulk like CoQ10 co-loaded liposome raw materials will empower your products and bring more significant health benefits.
If you need a complete experimental report, please click on the link below to view and download the relevant documents
https://www.natural-field.com/product-documents/
